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Fig. 1 | BioData Mining

Fig. 1

From: Revisiting the approaches to DNA damage detection in genetic toxicology: insights and regulatory implications

Fig. 1

List of various genetic and epigenetic toxicology testing methods with specificity to type of DNA alteration. MLA: Mouse lymphoma assay; HPRT: Hypoxanthine guanine phosphoribosyl transferase; TK: thymidine kinase gene mutation assay, TGR: Transgenic rodent mutation assay; Pig-A: phosphatidylinositol glycan class A (PIG-A) gene use for detecting somatic cell gene mutations; y-H2AX: phosphorylated form of histone H2AX serving as marker of double strand breaks; UDS: Unscheduled DNA Synthesis; TUNEL: Terminal deoxynucleotidyl transferase dUTP Nick-End Labeling; HCR: Host-cell reactivation; MN: micronucleus test; SCE: Sister Chromatid Exchange; CBMN: Cytokinesis-Block Micronucleus; FISH: Fluorescence In Situ Hybridization; ChIP: Chromatin Immunoprecipitation Sequencing; miRNA: microRNA; Line-1: Long Interspersed Nuclear Element-1; ATAC: Assay for Transposase-Accessible Chromatin

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ISSN: 1756-0381