Table 1 Comparison of SynTwin performance as measured by AUROC on various cancer datasets

90,000 (50%)

Breast [9]

mean

0.791

0.784

0.783

0.864

0.852

0.494

95% CI

[0.781, 0.800]

[0.774, 0.794]

[0.773, 0.793]

[0.857, 0.872]

[0.844, 0.860]

[0.482, 0.507]

30,000 (58.53%)

Ovary

mean

0.858

0.848

0.842

0.882

0.884

0.431

95% CI

[0.843,0.872]

[0.833,0.864]

[0.827,0.858]

[0.868,0.895]

[0.871,0.897]

[0.411,0.452]

20,000 (34.65%)

Cervix uteri

mean

0.720

0.708

0.702

0.835

0.828

0.496

95% CI

[0.700, 0.741]

[0.687, 0.729]

[0.680, 0.723]

[0.819, 0.851]

[0.811, 0.846]

[0.473, 0.519]

10,000 (38.49%)

Small intestine

mean

0.783

0.772

0.761

0.872

0.861

0.468

95% CI

[0.761,0.804]

[0.751,0.794]

[0.738,0.783]

[0.856,0.888]

[0.843,0.878]

[0.442,0.493]

5,000 (46.25%)

Hepatic flexure

mean

0.768

0.789

0.780

0.852

0.844

0.554

95% CI

[0.730,0.807]

[0.752,0.826]

[0.743,0.818]

[0.821,0.883]

[0.812,0.876]

[0.509,0.599]

3,000 (44.31%)

Nasopharynx

mean

0.597

0.594

0.578

0.708

0.709

0.552

95% CI

[0.540,0.654]

[0.541,0.648]

[0.524,0.632]

[0.657,0.759]

[0.660,0.759]

[0.493,0.612]

2,000 (56.83%)

Oropharynx

mean

0.671

0.683

0.664

0.746

0.768

0.438

95% CI

[0.608,0.733]

[0.620,0.746]

[0.599,0.728]

[0.687,0.804]

[0.712,0.820]

[0.368,0.508]

1,000 (59.56%)

Other urinary organs

mean

0.467

0.530

0.466

0.670

0.635

0.522

95% CI

[0.356,0.578]

[0.419,0.640]

[0.355,0.578]

[0.562,0.778]

[0.522,0.749]

[0.419,0.626]