Table 1 The top 20 proteins and biological functions of the 4 candidates and AML
Fostamatinib | Lasofoxifene | |
protein phosphorylation | ESR1 (2) | |
protein autophosphorylation | ESR2 (3) | |
intracellular signal transduction | CNR2 (1) | |
positive regulation of transcription by RNA polymerase II | GNA15 (4) | |
peptidyl-tyrosine phosphorylation | positive regulation of cytosolic calcium ion concentration | |
positive regulation of transcription, DNA-templated | negative regulation of transcription by RNA polymerase II | |
phosphorylation | positive regulation of transcription, DNA-templated | |
HSP90 AA1 (15) | positive regulation of DNA binding transcription factor activity | |
negative regulation of apoptotic process | positive regulation of transcription by RNA polymerase II | |
peptidyl-serine phosphorylation | transcription by RNA polymerase II | |
cellular protein modification process | regulation of cytosolic calcium ion concentration | |
negative regulation of transcription by RNA polymerase II | cellular response to estradiol stimulus | |
EGFR (12) | positive regulation of calcium ion transport into cytosol | |
regulation of RNA splicing | negative regulation of gene expression | |
NEK1 (337) | calcium ion transport into cytosol | |
negative regulation of transcription, DNA-templated | negative regulation of DNA binding transcription factor activity | |
positive regulation of gene expression | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway | |
LRRK2 (18) | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly | |
NTRK1 (10) | negative regulation of transcription, DNA-templated | |
APP (7) | negative regulation of production of miRNAs involved in gene silencing by miRNA | |
Zinc | L-Glutamic Acid | Acute Myeloid Leukemia |
CPN1 (979) | GRIN1 (48) | positive regulation of transcription by RNA polymerase II |
FN1 (6) | GRIK2 (63) | positive regulation of transcription, DNA-templated |
APOA1 (16) | GOT2 (70) | negative regulation of transcription, DNA-templated |
C3 (40) | SLC1 A1 (55) | negative regulation of transcription by RNA polymerase II |
IGHM (163) | GRIA2 (190) | MYC |
APP (2) | SLC25 A22 (171) | RUNX3 |
CLU (12) | GOT1 (29) | STAT3 |
C5 (209) | GRIN2 A (151) | IDH1 |
TP53 (4) | EARS2 (156) | ANXA2 |
C8 A (533) | SLC1 A3 (51) | GATA1 |
complement activation | GLUD2 (145) | NPM1 |
A2M (47) | GLUD1 (100) | SPI1 |
APLP1 (116) | SLC1 A2 (131) | PSIP1 |
APOE (9) | calcium ion transmembrane import into cytosol | GATA2 |
KNG1 (95) | GLS (180) | KRAS |
peptide cross-linking | response to ethanol | NSD1 |
C8G (179) | GRID2 (182) | GFI1 |
C8B (907) | TAT (20) | HSPB1 |
positive regulation of transcription by RNA polymerase II | FPGS (107) | EHMT2 |
HRNR (166) | GRM7 (166) | RUNX1 |