Table 4 Mediation effects identified from high-dimensional mediation analysis. We identified a total of 23 signals associated with 3 SNPs (rs10770119, rs4909932, rs7949917). We used PIP greater than zero as the criterion to select active mediators; the larger the PIP, the higher the likelihood that the mediator is active. Based on the estimate mediation effect provided by BAMA, we calculated the proportion of the mediation effect by dividing the estimated mediation effect by the total effect (the effect size from the GWAS between the SNP and the SPARE-AD index)
SNP | mediator | PIP | Estimate mediation effect | Proportion | |
|---|---|---|---|---|---|
rs10770119 | Mean of TLAC | 0.011 | 6.83E-03 | 25.80% | |
Mean of TAC | 0.001 | 2.39E-03 | 9.03% | ||
Mean of TLAC (8pm-10pm) | 0.001 | 5.03E-03 | 18.98% | ||
Mean of MVPA | 0.005 | 6.58E-03 | 24.85% | ||
Mean of M10 | 0.0005 | 1.95E-03 | 7.36% | ||
SD of TAC | 0.002 | 6.04E-03 | 22.82% | ||
SD of MVPA | 0.0015 | 5.02E-03 | 18.95% | ||
rs4909932 | Mean of TAC | 0.028 | 5.80E-03 | 22.00% | |
Mean of TLAC | 0.002 | 2.81E-03 | 10.67% | ||
Mean of TLAC (4pm-6pm) | 0.0005 | 2.74E-03 | 10.42% | ||
Mean of TLAC (6pm-8pm) | 0.0035 | 4.52E-03 | 17.15% | ||
Mean of TLAC (8pm-10pm) | 0.001 | 4.54E-03 | 17.23% | ||
Mean of MVPA | 0.0435 | 6.96E-03 | 26.41% | ||
SD of TAC | 0.0045 | 5.17E-03 | 19.62% | ||
SD of MVPA | 0.004 | 4.74E-03 | 17.99% | ||
rs7949917 | Mean of TAC | 0.028 | 5.80E-03 | 22.00% | |
Mean of TLAC | 0.002 | 2.81E-03 | 10.67% | ||
Mean of TLAC (4pm-6pm) | 0.0005 | 2.74E-03 | 10.42% | ||
Mean of TLAC (6pm-8pm) | 0.0035 | 4.52E-03 | 17.15% | ||
Mean of TLAC (8pm-10pm) | 0.001 | 4.54E-03 | 17.23% | ||
Mean of MVPA | 0.0435 | 6.96E-03 | 26.41% | ||
SD of TAC | 0.0045 | 5.17E-03 | 19.62% | ||
SD of MVPA | 0.004 | 4.74E-03 | 17.99% | ||