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Table 2 Sample characteristics of the UKBB data used in our study. We used t-test to test the group difference for BMI, Chi-square test to test the group difference for sex

From: High-dimensional mediation analysis reveals the mediating role of physical activity patterns in genetic pathways leading to AD-like brain atrophy

Characteristic

Positive

Negative

Total

p-value*

 

n1 = 560

n2 = 12,865

n = 13,425

 

Age, median (range)

71.57(45.65–81.82)

64.52(45.46–81.19)

64.83(45.46–81.82)

1.50E-97

Sex: Female, No. (%)

187(33)

7172(56)

7359(55)

3.67E-25

Sex: Male, No. (%)

373(67)

5693(44)

6066(45)

BMI, mean (SD)

26.26(4.13)

26.09(3.98)

26.10(3.98)

0.44

TAC_mean, mean (SD)

39,079(10596)

41,603(12144)

41,498(12094)

3.29E-06

TAC_sd, mean(SD)

7970(4500)

9042(6460)

8997(6393)

7.06E-05

MVPA_mean, mean(SD)

89(45)

99(51)

99(51)

2.07E-05

MVPA_sd, mean(SD)

37(19)

39(21)

39(21)

3.00E-02

PC1_mean, mean(SD)

0.2677(9.21)

0.0063(9.43)

0.0172(9.42)

0.52

PC1_sd, mean(SD)

8.13(3.12)

8.05(3.12)

8.06(3.12)

0.57

SPARE-AD index

0.21(0.20)

−0.73(0.34)

−0.69(0.39)

0.00E + 00

  1. *p-values are calculated by: Sex, Chi-square test; BMI, t-test; Age, TAC_mean, TAC_sd, MVPA_mean, MVPA_sd, PC1_mean, PC1_sd, Wilcoxon rank-sum test; SPARE-AD index, Kolmogorov-Smirnov test