Fig. 6
From: Predicting molecular initiating events using chemical target annotations and gene expression
Validation of candidate high-performance classifiers using exemplar chemicals. A) Workflow for converting LINCS profile MIE predictions to within-chemical percentile ranks. B) Heatmap of exemplar chemical percentile ranks for confirmed high performance classifiers. Heatmap columns are organized by classifier. Heatmap rows correspond to training-excluded exemplar chemicals. Cell shading represents the percentile rank for each chemical returned by each classifier. Dark green corresponds to a value of 1 (highest ranked prediction for chemical to activate the MIE) and white corresponds to 0 (lowest ranked prediction for chemical to activate the MIE). Cells marked with a ‘*’ indicate the corresponding exemplar chemical assigned to each MIE based on RefChemDB annotations